Where lymphatic filariasis has diminished since about the 1950s, it has most frequently, though not always, been a direct result of chemotherapeutic intervention against the parasite.
Diethylcarbamazine (DEC), a well-established drug, has been the single agent of chemotherapeutic control and has been successful in a wide variety of regimens.
This paper reviews the experience with one strategy : long-term, low-dose treatment through DEC-medicated common salt.
Diethylcarbamazine-medicated salt played a major role in the Chinese filariasis control program and has been successful in more limited trials in India, Brazil, and Tanzania.
It is not being used today in any endemic area, but the evidence suggests that it is safe, effective, and relatively inexpensive.
Mots-clés Pascal : Filariose, Nématodose, Helminthiase, Parasitose, Infection, Système lymphatique, Wuchereria bancrofti, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Brugia malayi, Chimiothérapie, Diéthylcarbamazine, Anthelminthique, Antiparasitaire, Sel, Alimentation, Long terme, Dose faible, Programme sanitaire, Lutte sanitaire, Prévention
Mots-clés Pascal anglais : Filariosis, Nematod disease, Helminthiasis, Parasitosis, Infection, Lymphatic system, Wuchereria bancrofti, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Brugia malayi, Chemotherapy, Anthelmintic, Parasiticid, Salt, Feeding, Long term, Low dose, Sanitary program, Sanitary control, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0553245
Code Inist : 002B02S06. Création : 09/06/1995.