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  1. Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black, and Asian men in Los Angeles, California.

    Article - En anglais

    Background :

    There is a large body of epidemiologic and experimental data that have identified a number of arylamines as human bladder carcinogens.

    Metabolic activation is required to biotransform these arylamines into their carcinogenic forms, and N-hydroxylation, which is catalyzed by the hepatic cytochrome P4501A2 isoenzyme, is generally viewed as the first critical step.

    On the other hand, the N-acetylation reaction, catalyzed by the hepatic N-acetyltransferase enzyme, represents a detoxification pathway for such compounds.

    The N-acetyltransferase enzyme is coded by a single gene displaying two phenotypes, slow and rapid acetylators.

    Mots-clés Pascal : Tumeur maligne, Vessie urinaire, Facteur risque, Phénotype acétylateur, Hémoglobine, Composé addition, Biphényl-4-ylamine, Carcinogène, Tabagisme, Caucasoïde, Négroïde, Mongoloïde, Epidémiologie, Mâle, Race, Ethnie, Etats Unis, Amérique du Nord, Amérique, Homme, Vessie pathologie, Voie urinaire pathologie, Appareil urinaire pathologie, Biphényl-"3"-ylamine

    Mots-clés Pascal anglais : Malignant tumor, Urinary bladder, Risk factor, Acetylator phenotype, Hemoglobin, Adduct, Carcinogen, Tobacco smoking, Caucasoid, Negroid, Mongoloid, Epidemiology, Male, Race, Ethnic group, United States, North America, America, Human, Bladder disease, Urinary tract disease, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0539081

    Code Inist : 002B14D02. Création : 199501.