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Comparative toxicity of non-steroidal anti-inflammatory agents.
PHARMACOLOGY AND THERAPEUTICS, vol. 62, n° 1-2, 1994, pages 175-191, réf. 2p., ISSN 0163-7258, GBR
GURKIRPAL SINGH, RAMEY (D.R.), MORFELD (D.), FRIES (J.F.)
Stanford univ school medicine. Dep medicine. Div immunology rheumatology. Palo Alto CA. USA
Comparative toxicity of non-steroidal anti-inflammatory drugs was assessed using the Stanford Toxicity Index consisting of weighted symptoms, laboratory abnormalities and hospitalizations in 2976 consecutively enrolled rheumatoid arthritis patients from eight data bank centers with 27,936 patient-years of observation.
Scores ranged from 1.77 (SE 0.20) for aspirin to 5.94 (SE 0.92) for meclofenamate, with many differences between drugs being 2-to 3-fold and highly statistically significant.
Results are consistent with our prior data, persist when assessed by several different scoring algorithms, are consistent across data bank centers and are consistent with data of others.
There are major and reproducible differences in the overall toxicity of different non-steroidal anti-inflammatory drugs.
Mots-clés BDSP : Etude comparée, Symptôme, Homme, Epidémiologie, Système ostéoarticulaire [pathologie], POLYARTHRITE RHUMATHOIDE
Mots-clés Pascal : Antiinflammatoire non stéroïde, Etude comparative, Article synthèse, Polyarthrite rhumatoïde, Symptomatologie, Homme, Toxicité, Surveillance biologique, Epidémiologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Non steroidal antiinflammatory agent, Comparative study, Review, Rheumatoid arthritis, Symptomatology, Human, Toxicity, Biological monitoring, Epidemiology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
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Inist-CNRS - Institut de l'Information Scientifique et TechniqueCote : 94-0537872
Code Inist : 002B02U10. Création : 199501.
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