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  1. Comparative toxicity of non-steroidal anti-inflammatory agents.

    Article - En anglais

    Comparative toxicity of non-steroidal anti-inflammatory drugs was assessed using the Stanford Toxicity Index consisting of weighted symptoms, laboratory abnormalities and hospitalizations in 2976 consecutively enrolled rheumatoid arthritis patients from eight data bank centers with 27,936 patient-years of observation.

    Scores ranged from 1.77 (SE 0.20) for aspirin to 5.94 (SE 0.92) for meclofenamate, with many differences between drugs being 2-to 3-fold and highly statistically significant.

    Results are consistent with our prior data, persist when assessed by several different scoring algorithms, are consistent across data bank centers and are consistent with data of others.

    There are major and reproducible differences in the overall toxicity of different non-steroidal anti-inflammatory drugs.

    Mots-clés Pascal : Antiinflammatoire non stéroïde, Etude comparative, Article synthèse, Polyarthrite rhumatoïde, Symptomatologie, Homme, Toxicité, Surveillance biologique, Epidémiologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Non steroidal antiinflammatory agent, Comparative study, Review, Rheumatoid arthritis, Symptomatology, Human, Toxicity, Biological monitoring, Epidemiology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0537872

    Code Inist : 002B02U10. Création : 199501.