The objective was to assess the degree of disease control and to evaluate the protective efficacy of licensed Haemophilus influenzae type b (Hib) conjugate vaccines (HbOC, PRP-OMP, PRP-D) used routinely in children 2 to 35 months of age.
We conducted a case-control study in Los Angeles County between January 1,1991, and December 31,1992, and a cohort analysis of Hib cases between 1983 and 1992.
For the case-control study 105 cases of invasive Hib disease were identified and 767 geographically and age-matched controls were selected by random digit telephone dialing.
Sixteen HbOC vaccine failures occurred>14 days after a single dose of vaccine, 6 vaccine failures after 2 doses and 3 failures after 3 doses ; 2 cases occurred 6 and 12 days, respectively, after an initial dose of HbOC.
Mots-clés Pascal : Haemophilus influenzae, Pasteurellaceae, Bactérie, Enfant, Homme, Calendrier vaccination, Vaccination, Immunoprophylaxie, Protection, Vaccin associé, Etude cas
Mots-clés Pascal anglais : Haemophilus influenzae, Pasteurellaceae, Bacteria, Child, Human, Vaccination schedule, Vaccination, Immunoprophylaxis, Protection, Mixed vaccine, Case study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0535566
Code Inist : 002B05B02E. Création : 199501.