Urinary biochemical indicators of renal injury were examined in 84 male and 38 female ferrochromium-producing workers exposed to water-soluble chromium compounds [Cr (VI) ]. The indicators examined included urinary chromium (U-Cr), alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), glutamic-oxalacetic and glutamic-pyruvic transaminases (GOT & GPT), lactate dehydrogenase (LDH), N-acetyl-bêta-D-glucosaminidase (NAG), total protein (TPr) and bêta2-microglobulin (bêta2-MG).
The U-Cr levels in the exposed group were approximately 1.8 times that of the control group.
Compared to controls, the activities of gamma-GT, NAG, ALP, GOT and LDH in the urine of workers were significantly increased whenever U-Cr concentration exceeded 45 mug/g creatinine.
Mots-clés Pascal : Chrome VI, Métal lourd, Rein pathologie, Exposition professionnelle, Homme, Toxicité, Fonction rénale, Surveillance biologique, Médecine travail, Appareil urinaire pathologie
Mots-clés Pascal anglais : Chromium VI, Heavy metal, Renal disease, Occupational exposure, Human, Toxicity, Renal function, Biological monitoring, Occupational medicine, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0525150
Code Inist : 002B03L05. Création : 199501.