A study was performed among 41 workers heavily exposed to a mixture of acrylamide and acrylonitrile in the city of Xinxiang, Henan province, People's Republic of China.
The workers underwent a complete medical and neurological examination and provided blood and urine for the determination of several biomarkers of exposure.
Among the exposed workers, signs and symptoms indicating peripheral neuropathy were found with statistically significant increased frequencies compared to a group of controls from the same city.
Based on neuropathic signs and symptoms and quantifiable indicators of peripheral nervous dysfunction, such as vibration thresholds and electroneuromyography measurements, a neurotoxicity index (NIn) specific for acrylamide-induced peripheral neuropathy was designed.
Mots-clés Pascal : Acrylamide, Système nerveux pathologie, Marqueur biologique, Exposition professionnelle, Homme, Toxicité, Adduit moléculaire, Surveillance biologique, Médecine travail, Hémoglobine
Mots-clés Pascal anglais : Acrylamide, Nervous system diseases, Biological marker, Occupational exposure, Human, Toxicity, Molecular adduct, Biological monitoring, Occupational medicine, Hemoglobin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0525140
Code Inist : 002B03L06. Création : 199501.