Cytogenetic assays in peripheral blood lymphocytes (PBL) have been used extensively to survey the exposure of humans to genotoxic agents.
The conceptual basis for this has been the hypothesis that the extent of genetic damage in PBL reflects critical events for carcinogenic processes in target tissues.
Until now, no follow-up studies have been performed to assess the predictive value of these methods for subsequent cancer risk.
In an ongoing Nordic cohort study of cancer incidence, 3182 subjects were examined between 1970 and 1988 for chromosomal aberrations (CA), sister chromatid exchange or micronuclei in PBL.
Mots-clés Pascal : Tumeur maligne, Facteur risque, Prédiction, Evaluation, Lymphocyte, Aberration chromosomique, Echange chromatide soeur, Micronucléus, Homme, Méthode étude, Etude comparative, Epidémiologie, Pays Scandinaves, Europe
Mots-clés Pascal anglais : Malignant tumor, Risk factor, Prediction, Evaluation, Lymphocyte, Chromosomal aberration, Sister chromatid exchange, Micronucleus, Human, Investigation method, Comparative study, Epidemiology, Scandinavia, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0489758
Code Inist : 002B04B. Création : 199501.