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  1. Functional and immunological relevance of ghe COOH-terminal extension of human chorionic gonadotropin bêta : implications for the WHO birth control vaccine.

    Article - En anglais

    The World Health Organisation (WHO) Task Force on Birth Control Vaccines has selected the pregnancy hormone human chorionic gonadotropin (hCG) as a target molecule for a contraceptive vaccine.

    A synthetic peptide antigen corresponding to the amino acid sequence 109-145 of the carboxyl-terminal portion of the hCGbêta-subunit (hCGbêtaCTP), which is supposed to elicit hCG-immunoneutralizing antibodies, has been submitted to clinical trails.

    Recent findings suggest that hCGbêtaCTP does not play a role in the biological activity of hCG.

    This raises the question concerning the assumed mechanism of action of the hCGbêtaCTP-based birth control vaccine.

    We therefore investigated the immunoneutralizing capacity of antibodies directed against hCGbêtaCTP.

    Mots-clés Pascal : Caractérisation, Homme, OMS, Gonadotrophine chorionique, Contrôle naissance, Vaccin

    Mots-clés Pascal anglais : Characterization, Human, WHO, Chorionic gonadotropin, Birth control, Vaccine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0485915

    Code Inist : 002B30A01C. Création : 199501.