Lethal midline granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML).
WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells.
In this report, twenty-two cases of LMG in Okinawa were examined.
The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic.
Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43+and simultaneously contained Epstein-Barr viral genome in their nuclei.
Mots-clés Pascal : Granulome ligne médiane, Inflammation, Réticulose histiocytaire maligne, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Etiologie, Epidémiologie, Japon, Asie, Réaction chaîne polymérase, Hybridation moléculaire, In situ, Homme, ORL pathologie, Hémopathie maligne, Exploration, Biologie moléculaire, Génétique, Okinawa
Mots-clés Pascal anglais : Midline granuloma, Inflammation, Malignant histiocytosis, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Etiology, Epidemiology, Japan, Asia, Polymerase chain reaction, Molecular hybridization, In situ, Human, ENT disease, Malignant hemopathy, Exploration, Molecular biology, Genetics
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0480528
Code Inist : 002B19B. Création : 199501.