Does non-diabetic hyperglycemia predict future IHD ? Evidence from the caerphilly and speedwell studies.
We have examined the risk of subsequent ischemic heart disease (IHD) in men according to their initial fasting plasma glucose level in a prospective cohort study (Caerphilly Collaborative Study) of 4860 middle aged men from South Wales and Bristol, U.K. Ninety-four men reported themselves to be diabetic at initial screening and fasting venous plasma glucose levels were determined in these men and in a further 4519 non-diabetic men.
At follow-up new IHD events occurred twice as commonly in diabetics compared to non-diabetics and overall mortality was increased 4-fold.
Among non-diabetics however, increased IHD events only occurred in men with fasting values at the upper end of the distribution of baseline plasma glucose values [at 6.8 mmol/l (122 mg/dl) or more].
Mots-clés Pascal : Ischémie, Myocarde, Epidémiologie, Diabète, Glucose, Hyperglycémie, Homme, Etude longitudinale, Royaume Uni, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie, Endocrinopathie
Mots-clés Pascal anglais : Ischemia, Myocardium, Epidemiology, Diabetes mellitus, Glucose, Hyperglycemia, Human, Follow up study, United Kingdom, Europe, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease, Endocrinopathy
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0466055
Code Inist : 002B12A03. Création : 199501.