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  1. A second-generation study of 427 probands with congenital heart defects and their 837 children.

    Article - En anglais


    This study attempted to answer the question, Do mothers with congenital cardiovascular defects have more affected children than fathers with cardiac anomalies?


    In the 1950s to 1960s, concern was expressed about the safety of pregnancy in women with cardiac anomalies and the possibility of inheritance.


    In a prospective study over 25 years, 236 women with cardiac defects were followed through pregnancy, and their 418 offspring were examined during their 1st 3 years.

    A high incidence of congenital cardiac malformations was noted.

    Then, a retrospective study of 191 men from the same clinic group and their total family (419 children) was performed to compare the incidence of affected children between the maternal study and this subsequent paternal study.

    Mots-clés Pascal : Cardiopathie, Congénital, Etude familiale, Incidence, Origine paternelle, Origine maternelle, Epidémiologie, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Maladie congénitale

    Mots-clés Pascal anglais : Heart disease, Congenital, Family study, Incidence, Paternal origin, Maternal origin, Epidemiology, Human, United States, North America, America, Cardiovascular disease, Congenital disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0462828

    Code Inist : 002B12A08. Création : 199406.