To study perinatal transmission of hepatitis C virus (HCV), 15 anti-HCV-positive carrier mothers without human immunodeficiency virus coinfection were recruited.
At delivery, maternal blood was taken and anti-HCV titer was determined and HCV RNA measured in each serum sample by reverse transcription polymerase chain reaction (PCR).
A competitive PCR was used in selected samples to quantitate HCV concentration.
The 1 5 neonates were followed regularly for 1 year and their sera were also assayed for anti-HCV and for HCV RNA by reverse transcription PCR.
All the mothers were positive for HCV RNA.
Mots-clés Pascal : Virémie, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Facteur risque, Hépatite virale C, Taiwan, Asie, RNA, Périnatal, Epidémiologie, Nouveau né, Homme, Mère pathologie, Appareil digestif pathologie, Foie pathologie, Transmission verticale
Mots-clés Pascal anglais : Viremia, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, Risk factor, Viral hepatitis C, Taiwan, Asia, RNA, Perinatal, Epidemiology, Newborn, Human, Maternal diseases, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0462381
Code Inist : 002B05C02G. Création : 199406.