Apparent selection against transmission of zidovudine-resistant human immunodeficiency virus type 1 variants.
The sexual transmission of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) variants was investigated in 5 donor-recipient pairs in which all donors and none of the recipients had received zidovudine treatment.
The virus isolates were tested for sensitivity to zidovudine (IC50) in vitro using blood donor lymphocytes.
A region of the HIV-1 pol gene was also directly sequenced by a solid-phase sequencing method.
Four donors were shown to have zidovudine-resistant HIV-1 variants.
Two of these patients had a single mutation (Thr215-Tyr), and 2 had a double mutation (Met41-Leu and Thr215-Tyr) that previously has been shown to confer zidovudine resistance.
Mots-clés Pascal : SIDA, Virose, Infection, Résistance, Variant génétique, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Sélection, Transmission homme homme, Homme, Zidovudine, Antiviral, Epidémiologie, Pyrimidine nucléoside, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Resistance, Genetic variant, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Selection, Transmission from man to man, Human, Antiviral, Epidemiology, Pyrimidine nucleoside, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0462374
Code Inist : 002B06D01. Création : 199406.