Fibrinolysis is dependent upon plasminogen activator (tPA) activity while high fibrinogen levels increase the risk of thromboembolic events.
From a cross-sectional population sample of 1558 men and women aged 25 to 64 years, plasma fibrinogen, tPA activity and plasminogen activator inhibitor-1 (PAI) activity were determined using specific assays.
Associations with body mass index (BMI), waist-hip ratio (WHR), serum lipids and blood pressure were calculated with uni- and multivariate models where age and smoking were also introduced.
In men age, truncal obesity, short height and low HDL cholesterol independently predicted fibrinogen (R2 0.20) while in women obesity per se, total cholesterol, systolic blood pressure, smoking and age were predictors (R2 0.29).
Mots-clés Pascal : Fibrinogène, Fibrinolyse, t-Plasminogen activator, Serine endopeptidases, Proteinases, Hydrolases, Enzyme, Inhibiteur enzyme, Epidémiologie, Homme, Anthropométrie, Biométrie corporelle, Lipide, Pression sanguine, Hémodynamique, Appareil circulatoire, Facteur risque, Suède, Europe
Mots-clés Pascal anglais : Fibrinogen, Fibrinolysis, t-Plasminogen activator, Serine endopeptidases, Proteinases, Hydrolases, Enzyme, Enzyme inhibitor, Epidemiology, Human, Anthropometry, Corporal biometry, Lipids, Blood pressure, Hemodynamics, Circulatory system, Risk factor, Sweden, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0460877
Code Inist : 002B29A. Création : 199406.