logo BDSP

Base documentaire

  1. Thin-layer chromatographic detection of cocaethylene in human urine.

    Article - En anglais

    A thin-layer chromatographic method was developed for the detection of cocaethylene and cocaine in human urine.

    Following a standard solid-phase extinction of urine buffered to pH 9.3, the concentrated extract was chromatographed in a solvent consisting of hexane:toluene:diethylamine (65:20:5 mL).

    Both cocaethylene and cocaine were visualized with iodoplatinate spray.

    Exclusive of the type of extraction used, the detection limit itself was 16 nmol (5 mug) for either compound.

    The method was applied to urine samples of 13 patients who had ingested cocaine with ethanol.

    Statistically significant correlations were noted between the intensity of the urine thin-layer chromatographic detection and the measured urine concentrations of cocaethylene and cocaine.

    Mots-clés Pascal : Toxicomanie, Dépistage, Homme, Urine, Cocaïne, Chromatographie couche mince, Analyse chimique, Cocaéthylène, Ethylcocaïne

    Mots-clés Pascal anglais : Drug addiction, Medical screening, Human, Urine, Cocaine, Thin layer chromatography, Chemical analysis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0455521

    Code Inist : 002B03D. Création : 199406.