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  1. The evolution of clinical practice and time trends in drug effects.

    Article - En anglais

    Evidence from contemporary studies suggests that the quantification of adverse drug effects through state-of-the-art non-experimental methods may be confounded by some aspects of clinical practice.

    Support for this hypothesis is manifest in the finding that drug effects sometimes show within-study time trends when clinical practice with regard to drug use is evolving.

    Three studies which show simultaneous trends in prescription frequency and drug effects are discussed as examples.

    These include a study of benzodiazepines in the etiology of hip fracture, postmenopausal estrogens as a preventive for major coronary disease and human insulin as a risk factor for severe hypoglycemia.

    Mots-clés Pascal : Epidémiologie, Médicament, Toxicité, Méthodologie, Biais

    Mots-clés Pascal anglais : Epidemiology, Drug, Toxicity, Methodology, Bias

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0448747

    Code Inist : 002B02A07. Création : 199406.