Methadone treatment as a determinant of HIV risk reduction among injecting drug users: a nested case-control study.
In order to evaluate the protective effect of methadone treatment on HIV infection, we performed a nested case-control study on seroconverters (cases) who were part of a cohort of HIV-negative infecting drug users (IDUs) (controls).
Controls were matched with cases by sex, age, duration of drug use and follow-up time.
Information on methadone treatment in the year prior to seroconversion was collected using clinical registries.
Univariate and multivariate conditional logistic regression were used to identify variables related to HIV-seroconversion.
The study included 40 cases and 40 controls.
Univariate analysis showed the following variables to be associated to HIV seroconversion: number of cycles of treatment, daily dose and time out of treatment.
Mots-clés Pascal : Toxicomanie, Voie intraveineuse, Traitement substitutif, Méthadone, Analgésique narcotique, Sevrage toxique, Prévention, SIDA, Virose, Infection, Immunopathologie, Immunodéficit, Etude longitudinale, Homme
Mots-clés Pascal anglais : Drug addiction, Intravenous administration, Replacement therapy, Narcotic analgesic, Poison withdrawal, Prevention, AIDS, Viral disease, Infection, Immunopathology, Immune deficiency, Follow up study, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0444135
Code Inist : 002B03D. Création : 199406.