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Antibody responses to the three genomic groups of Borrelia burgdorferi in European lyme borreliosis.
JOURNAL OF INFECTIOUS DISEASES, vol. 169, n° 2, 1994, pages 313-318, 32 réf., ISSN 0022-1899, USA
DRESSLER (F.), ACKERMANN (R.), STEERE (A.C.)
Tufts univ school medicine. New England medical cent. Div rheumatology. Immunology. Boston MA. USA
The antibody responses to the three genomic groups of Borrelia burgdorferi (B. burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii) were determined in various manifestations of Lyme borreliosis.
The geometric mean antibody titers in each patient group, determined by ELISA, were similar with each antigen preparation.
By Western blotting, however, patients with meningopolyneuritis tended to respond to more spirochetal polypeptides of B. garinii, the group 2 strain, whereas those with arthritis recognized more antigens of B. afzelii, the group 2 strain (P<.03), as did those with acrodermatitis.
Only I patient each with erythema migrans, arthritis, or acrodermatitis had weak reactivity with outer surface protein A (OspA), and none responded to OspB.
Mots-clés BDSP : Bactériose, Infection, Bactérie, Europe, Symptôme, Anticorps, Homme, Epidémiologie
Mots-clés Pascal : Borréliose, Spirochétose, Bactériose, Infection, Borrelia burgdorferi, Spirochaetaceae, Spirochaetales, Bactérie, Europe, Lyme maladie, Génome, Symptomatologie, Anticorps, Exploration immunologique, Homme, Epidémiologie, Groupe génomique
Mots-clés Pascal anglais : Borrelia infection, Spirachaetosis, Bacteriosis, Infection, Borrelia burgdorferi, Spirochaetaceae, Spirochaetales, Bacteria, Europe, Lyme disease, Genome, Symptomatology, Antibody, Immunological investigation, Human, Epidemiology
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Code Inist : 002B05B02L6. Création : 199406.
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