Intervention of maternal transmission of HTLV-1 in Nagasaki, Japan.
International Association for Comparative Research on Leukemia and Related Diseases. Symposium. Montreal PQ (CAN), 1993/07/11.
Seroepidemiological and laboratory virological evidences strongly suggested that endemicity of HTLV-1 in Nagasaki Japan depends on maternal infant infections via breast milk.
The most obvious way to prove this concept was an intervention study with refraining from breast-feeding by carrier mothers.
Most infected babies seroconverted by the age of 12 months, which made it possible to diagnose the infection at the age of 12 months for the statistical purpose.
Serology and PCR on both adults and children were consistent each other, suggesting the absence of seronegative carriers.
The intervention study revealed that approximately 80% of maternal infection was prevented by refraining from breast feeding by carrier mothers.
Mots-clés Pascal : Virose, Infection, Virus HTLV1, Retroviridae, Virus, Allaitement, Mode transmission, Transmission, Périnatal, Endémie, Japon, Asie, Prévention, Epidémiologie, Enfant, Homme
Mots-clés Pascal anglais : Viral disease, Infection, HTLV-I virus, Retroviridae, Virus, Breast feeding, Transmission mode, Transmission, Perinatal, Endemy, Japan, Asia, Prevention, Epidemiology, Child, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0439544
Code Inist : 002B19B. Création : 199406.