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  1. Lethality due to uranium poisoning is prevented by ethane-1-hydroxy-1,1-bisphosphonate (EHBP).

    Article - En anglais

    The processes of uranium extraction, purification, and manufacture involve the risk of chemical intoxication.

    Acute uranium poisoning elicits renal failure which in turn may lead to death.

    Great efforts have been put into the search for a protective agent for acute uranium poisoning.

    Several chelating agents such as EDTA, Tiron, DTPA, or aminosalicylic acid have been experimentally assayed.

    However, even when these agents are able to reduce the mortality none of them achieve 100% survival.

    We herein present the use of EHBP to prevent mortality due to uranium poisoning.

    Rats weighing 14 g were employed in two different experiments: A) The surviving animals were killed on the 60th day; and B) The animals were killed on the 9th day.

    Mots-clés Pascal : Intoxication, Uranium, Rein, Chélateur, Dose létale, Appareil urinaire pathologie, Rat, Rodentia, Mammalia, Vertebrata, Animal, Analyse risque

    Mots-clés Pascal anglais : Poisoning, Uranium, Kidney, Chelating agent, Lethal dose, Urinary system disease, Rat, Rodentia, Mammalia, Vertebrata, Animal, Risk analysis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0427809

    Code Inist : 002B03O. Création : 199406.