A hepatitis immunization field trial, using a Chinese hamster ovary (CHO) cell recombinant vaccine, was implemented for newborns in the Austral archipelago of French Polynesia in 1988.
Three different schedules were used:
(1) four vaccine doses at months (M) M0,
M2 and M12;
(2) three vaccine doses at M0,
M1 and M6;
and (3) three vaccine doses at M0,
M1 and M12.
The programme evaluation was performed yearly at fixed dates, i.e. October-November 1989, 1990 and 1991.
After the third year, of the 582 children who received one or more doses of vaccine, four were HBsAg carriers.
After one or two doses, 88 and 98%, respectively, had seroconverted for at least one of the two measured antibodies, anti-HBs or anti pre-S2.
Mots-clés Pascal : Nouveau né, Virus hépatite B, Vaccination, Immunoprotection, Evaluation performance, Vaccin, Hépatite virale B, Polynésie française, Protéine recombinante, Prévention, Homme, Hepadnaviridae, Virus, Virose, Infection, Polynésie, Océanie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Newborn, Hepatitis B virus, Vaccination, Immunoprotection, Performance evaluation, Vaccine, Viral hepatitis B, French Polynesia, Recombinant protein, Prevention, Human, Hepadnaviridae, Virus, Viral disease, Infection, Polynesia, Oceania, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0421437
Code Inist : 002A05C07. Création : 199406.