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  1. Dose-dependent tolerance to ozone. I: Tracheobronchial epithelial reorganization in rats after 20 months' exposure.

    Article - En anglais

    Two salient features of the pulmonary response to reactive oxidant air pollutants such as ozone are the heterogeneity of response by site within the respiratory tract and the development of tolerance to injury with repeated exposure.

    The purpose of this study was to establish whether the develoment of tolerance to long-term exposure is associated with changes in the tracheobronchial epithelium.

    Male F344-N rats were exposed ro 0, 0.12, 0.5, or 1.0 ppm ozone 6 hours/day for 5 days/week for 20 months and killed 1 week post-exposure.

    Mots-clés Pascal : Appareil respiratoire pathologie, Exploration, Animal, Anatomopathologie, Etude expérimentale, Morphométrie, Toxicologie, Polluant, Air, Relation dose réponse, Epithélium, Bronchotrachéal, Ozone, Toxicité, Rat, Rodentia, Mammalia, Vertebrata

    Mots-clés Pascal anglais : Respiratory disease, Exploration, Animal, Pathology, Experimental study, Morphometry, Toxicology, Pollutant, Air, Dose activity relation, Epithelium, Tracheobronchial, Ozone, Toxicity, Rat, Rodentia, Mammalia, Vertebrata

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0367207

    Code Inist : 002B03M02. Création : 199406.