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  1. Polychlorinated biphenyls (PCBs) : environmental impact, biochemical and toxic responses, and implications for risk assessment.

    Article - En anglais

    Commercial polychlorinated biphenyls (PCBs) and environmental extracts contain complex mixtures of congeners that can be unequivocally identified and quantitated.

    Some PCB mixtures elicit a spectrum of biochemical and toxic responses in humans and laboratory animals and many of these effects resemble thosse caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatic hydrocarbons, which act through the aryl hydrocarbon (Ah)-receptor signal transduction pathway.

    Structure-activity relationships developed for PCB congeners and metabolites have demonstrated that several structural classes of compounds exhibit diverse biochemical and toxic responses.

    Mots-clés Pascal : Biphényle(polychloro), Polluant, Environnement, Toxicité, Association toxique, Relation structure activité, Evaluation, Risque, Animal, Homme, Article synthèse, Mélange, Carcinogène, Facteur équivalence toxique

    Mots-clés Pascal anglais : Polychlorobiphenyl, Pollutant, Environment, Toxicity, Toxic association, Structure activity relation, Evaluation, Risk, Animal, Human, Review, Mixture, Carcinogen

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0360187

    Code Inist : 002B03M01. Création : 199406.