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  1. The multifactorial and multistage character of protective immunity to Plasmodium falciparum, naturally acquired by an indigenous population in Burkina Faso.

    Article - En anglais

    In malaria-endemic areas, protective immunity is acquired gradually.

    Some authors have proposed that different stages can be distinguished during development.

    To test this hypothesis, several in vitro assays of the host immune response to P. falciparum were performed in three groups of individuals: « unprotected » children with clinical attacks, « semi-immune » children, without clinical attacks but with transient high parasitaemias during the transmission period, and'protected'adults with low residual parasitaemias.

    By comparison of immune responses in these groups and multifactorial analyses, discriminant factors and potential protective mechanisms were identified.

    Mots-clés Pascal : Plasmodium falciparum, Sporozoa, Protozoa, Immunoprotection, Immunité acquise, Immunité naturelle, Paludisme, Protozoose, Infection, Immunité cellulaire, Immunité humorale, Réponse immune, Homme, Burkina Faso, Afrique, Analyse multivariable

    Mots-clés Pascal anglais : Plasmodium falciparum, Sporozoa, Protozoa, Immunoprotection, Acquired immunity, Natural immunity, Malaria, Protozoal disease, Infection, Cellular immunity, Humoral immunity, Immune response, Human, Burkina Faso, Africa, Multivariate analysis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0357923

    Code Inist : 002B05E02B4. Création : 199406.