The rates of DNA single-strand breaks in peripheral lymphocytes of 41 persons administering anesthesia daily and 44 control persans were determined by nucleoid segmentation.
There is a significantly higher rate of DNA single-strand breaks in nonsmoking anesthesia persons than in nonsmoking control persons (P<0.01).
Smoking anesthesia persons and smoking control persons presented increased rates of DNA single-strand breaks.
Nonsmoking nurse anesthetists showed an insignificantly higher rate of damage than nonsmoking anesthesiologists.
DNA single-strand breaks indicate damage before the start of DNA repair.
Therefore, detected DNA single-strand breaks may be reversible.
As not every DNA repair is perfect, increased rates of DNA single-strand breaks may possibly lead to imeversible DNA damage.
Mots-clés Pascal : Anesthésique général, Toxicité, Personnel sanitaire, Exposition professionnelle, Médecine travail, Homme, Lymphocyte, Cassure monocaténaire, Cassure chromosomique, DNA, Composé volatil
Mots-clés Pascal anglais : General anesthetic, Toxicity, Health staff, Occupational exposure, Occupational medicine, Human, Lymphocyte, Single strand break, Chromosome break, DNA, Volatile compound
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0356716
Code Inist : 002B02U10. Création : 199406.