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  1. DNA single-strand breaks in peripheral lymphocytes of clinical personnel with occupational exposure to volatile inhalational anesthetics.

    Article - En anglais

    The rates of DNA single-strand breaks in peripheral lymphocytes of 41 persons administering anesthesia daily and 44 control persans were determined by nucleoid segmentation.

    There is a significantly higher rate of DNA single-strand breaks in nonsmoking anesthesia persons than in nonsmoking control persons (P<0.01).

    Smoking anesthesia persons and smoking control persons presented increased rates of DNA single-strand breaks.

    Nonsmoking nurse anesthetists showed an insignificantly higher rate of damage than nonsmoking anesthesiologists.

    DNA single-strand breaks indicate damage before the start of DNA repair.

    Therefore, detected DNA single-strand breaks may be reversible.

    As not every DNA repair is perfect, increased rates of DNA single-strand breaks may possibly lead to imeversible DNA damage.

    Mots-clés Pascal : Anesthésique général, Toxicité, Personnel sanitaire, Exposition professionnelle, Médecine travail, Homme, Lymphocyte, Cassure monocaténaire, Cassure chromosomique, DNA, Composé volatil

    Mots-clés Pascal anglais : General anesthetic, Toxicity, Health staff, Occupational exposure, Occupational medicine, Human, Lymphocyte, Single strand break, Chromosome break, DNA, Volatile compound

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0356716

    Code Inist : 002B02U10. Création : 199406.