OBJECTIVES-A recent review or meta-analysis of epidemiologic studies concluded that persons with asbestos-related pleural plaques do not have an increased risk of lung cancer in the absence of parenchymal asbestosis.
The reviewer inferred that this conclusion provided indirect supportive evidence for the proposition that asbestosis is a necessary precursor of asbestos-related lung cancer.
The objective of the present communication is to contest these claims.
METHODS-Finnish epidemiologic data and population statistics were used to estimate the apparent risk ratio of lung cancer associated with radiographic signs of pleural plaques.
Power calculations were applied to compute the needed population sizes to demonstrate that the association is statistically significant.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Epidémiologie, Métaanalyse, Homme, Carcinogène, Plaque pleurale, Amiante, Fibre minérale, Finlande, Europe, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Epidemiology, Metaanalysis, Human, Carcinogen, Pleural plate, Asbestos, Mineral fiber, Finland, Europe, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0337782
Code Inist : 002B11A. Création : 199406.