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  1. Prognostic assessment from studies with non-randomized treatment assignment.

    Article - En anglais

    In clinical practice, prognostic factors are primarily used to identify and select patients with a relatively poor prognosis who may need more aggressive treatment in order to improve their prognosis.

    Preferably, assessment of the ability of prognostic factors to distinguish these high risk patients from low risk patients should take place in the absence of such prognosis-modifying adjuvant therapy.

    Adjuvant therapy may dilute the effect of prognosticators (covariate-treatment interactions) and such a situation may go unnoticed in tests for interaction because of their low statistical power.

    Mots-clés Pascal : Pronostic, Homme, Méthodologie, Randomisation, Traitement, Choix, Analyse statistique, Biais

    Mots-clés Pascal anglais : Prognosis, Human, Methodology, Randomization, Treatment, Choice, Statistical analysis, Bias

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0314109

    Code Inist : 002B30A01A1. Création : 199406.