Hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Chinese : a case-control study.
To assess whether hepatitis B and C virus infection were risk factors for hepatocellular carcinoma (HCC), antibody to hepatitis C virus (anti-HCV, hepatitis B surface antigen and e antigen (HBsAg and HBeAg) were tested in 150 HCC patients.
Another 150 case-control pairs matched individually by sex and age were also enrolled.
Univariate analysis demonstrated that both the anti-HCV and the carrier status of HBsAg and HBeAg were signiFcantly associated with HCC.
Multi-variate analysis revealed that both anti-HCV and HBsAg were risk factors for HCC.
The population-attributable risk was estimated as 14.2% for anti-HCV alone, 59.4% for HBsAg alone and 8.0% for both anti-HCV and HBsAg in Taiwan.
In conclusion, both hepatitis B and C virus infection are independent risk factors for HCC in Chinese in southern Taiwan.
Mots-clés Pascal : Hépatome, Epithélioma, Foie, Facteur risque, Hépatite virale B, Virose, Infection, Hépatite virale C, Epidémiologie, Taiwan, Asie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Etude cas témoin
Mots-clés Pascal anglais : Liver cell carcinoma, Carcinoma, Liver, Risk factor, Viral hepatitis B, Viral disease, Infection, Viral hepatitis C, Epidemiology, Taiwan, Asia, Human, Digestive diseases, Hepatic disease, Malignant tumor, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0311918
Code Inist : 002B13C01. Création : 199406.