The prevalence of antithrombin (AT) deficiency in the general population has been variously estimated to be between 0.05 and 5 per 1,000 in the population; 2,491 blood donors were screened in an attempt to clarify this issue using plasma samples taken from the blood donor units.
From this initial population, 122 individuals were identified as having plasma AT levels lower than 2 standard deviations below the normal mean.
Twenty-two samples had evidence that thrombin had been generated during blood collection and the remaining cohort of 100 blood donors were asked to return but only 59 complied.
The data obtained from these 59 were compared with that from 51 age and sex-matched control blood donors.
Mots-clés Pascal : Déficit, Antithrombine, Donneur sang, Prévalence, Etude transversale, Ontario, Canada, Amérique du Nord, Amérique, Epidémiologie, Homme, Coagulopathie, Hémopathie
Mots-clés Pascal anglais : Deficiency, Antithrombin, Blood donor, Prevalence, Cross sectional study, Ontario, Canada, North America, America, Epidemiology, Human, Coagulopathy, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0303987
Code Inist : 002B19C. Création : 199406.