Occupational asthma is characterized by variable airflow abstruction occurring in the workplace.
The presence of airways inflammation and hyperreactivity provides further evidence of the disease.
Since its pathogenic mechanism(s) are unknown, animal models have been developed to investigate the various disease processes, as well as to enable study of environmental and genetic factors which may contribute to disese development.
Numerous parameters can be measured in animal systems, including specific and total immunoglobulin E (IgE), pulmonary eosinophilia, diaphragm contractions and airflow muscle hypertrophy.
Mots-clés Pascal : Asthme, Exposition professionnelle, Médecine travail, Modèle animal, Etiopathogénie, Animal, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Asthma, Occupational exposure, Occupational medicine, Animal model, Etiopathogenesis, Animal, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0302068
Code Inist : 002B11B. Création : 199406.