Mechanisms and pathology of occupational asthma.
Since the pathogenesis and the pathological features of occupational asthma are similar to those of nonoccupational asthma, the former represents a very useful model for the investigation of the pathogenesis of asthma in general.
More than one mechanism may be operative in occupational asthma.
Among the mechanisms proposed, immunological mechanisms and airway inflammation play an important role.
There is evidence to confirm that T-lymphocyte activation and local accumulation in the bronchial wall of activated eosinophils occurs in asthma of diverse aetiology, i.e. immunoglobulin E (IgE)-mediated, occupational and intrinsic.
Mots-clés Pascal : Asthme, Exposition professionnelle, Homme, Médecine travail, Physiopathologie, Inflammation, Immunité, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Asthma, Occupational exposure, Human, Occupational medicine, Pathophysiology, Inflammation, Immunity, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0302067
Code Inist : 002B11B. Création : 199406.