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  1. Comparison of liquid and dried blood for neonatal hemoglobinopathy screening : laboratory and programmatic issues.

    Article - En anglais


    To compare laboratory and programmatic issues in neonatal hemoglobin screening in two systems using either liquid cord blood or heel puncture blood dried on filter paper (DB) to determine the accuracy of hemoglobin phenotype; the collection rate of cord blood versus DB; and the types of and reasons for errors.


    Cord blood samples for 6904 newborns were analyzed by electrophoresis in a large hospital laboratory.

    DB samples on the same cohort were analyzed by isoelectric focusing in a state public health laboratory.


    Interlaboratory concordance was 99.4% for 6904 matched specimen pairs, which included 27 disease and 596 carrier phenotypes.

    In 42 pairs, discordances for potential disease phenotypes occurred with cord blood samples.

    Mots-clés Pascal : Hémoglobinopathie, Congénital, Dépistage, Nouveau né, Homme, Etude comparative, Evaluation performance, Anémie hématie falciforme, Technique, Diagnostic, Phénotype, Hémoglobine, Géorgie, Etats Unis, Amérique du Nord, Amérique, Hémopathie, Anémie hémolytique, Maladie héréditaire

    Mots-clés Pascal anglais : Hemoglobinopathy, Congenital, Medical screening, Newborn, Human, Comparative study, Performance evaluation, Sickle cell anemia, Technique, Diagnosis, Phenotype, Hemoglobin, Georgia, United States, North America, America, Hemopathy, Hemolytic anemia, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0292986

    Code Inist : 002B24O10. Création : 199406.