A high level of available tissue iron may increase the risk of cancer through its contribution to the production of free oxygen radicals.
Serum iron, total iron-binding capacity (TIBC) and transferrin saturation levels were studied for their prediction of different cancers in a cohort of 41,276 men and women aged 20-74 years and initially free from cancer.
During a mean follow-up of 14 years, 2,469 primary cancer cases were diagnosed.
Excess risks of colorectal and lung cancers were found in subjects with transferrin saturation level exceeding 60%. The relative risks, adjusted for age, sex and smoking, were 3.04 for colorectal cancer and 1.51 for lung cancer, in comparison with subjects having lower levels.
Mots-clés Pascal : Tumeur maligne, Facteur risque, Fer, Réserve, Epidémiologie, Finlande, Europe, Homme
Mots-clés Pascal anglais : Malignant tumor, Risk factor, Iron, Reserve, Epidemiology, Finland, Europe, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0287811
Code Inist : 002B04B. Création : 199406.