Moderate elevation of body iron level and increased risk of cancer occurrence and death.
The purpose of the study was to address the hypothesis that elevated body iron increases the risk of cancer occurrence and death, and to determine the dose response.
Subjects were 3,287 men and 5,269 women participating in the first National Health and Nutrition Examination Survey who had a transferrin saturation determination at enrollment (1971-1975), who remained alive and cancer-free for at least 4 years, and who were followed to 1988 for cancer outcome.
Among 379 men who developed cancer over the study period, the mean transferrin saturation at enrollment was 32.1% whereas among 2,908 who remained cancer-free it was 30.1%; the difference for mortality was 32.3% among 233 deaths vs. 30.8% among 3,054 men not dying of cancer.
Mots-clés Pascal : Tumeur maligne, Sidérémie, Facteur risque, Mortalité, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme
Mots-clés Pascal anglais : Malignant tumor, Sideremia, Risk factor, Mortality, Epidemiology, United States, North America, America, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0287808
Code Inist : 002B04B. Création : 199406.