Clinical consequences of antiphospholipid antibodies : an historic cohort study.
To determine the risk of antiphospholipid antibody-related disorders in women with elevated levels of these antibodies.
We used an historic cohort study design.
Surveys of medical and obstetric histories for the interval from initial antibody testing to the time of patient interview were used to calculate age-adjusted rates for the development of medical disorders associated with antiphospholipid antibodies.
The cohort included 130 women with lupus anticoagulant, medium to high levels of immunoglobulin G anticardiolipin antibodies, or both.
The median interval of study was 3.2 years (range 0.7-9.5, mean 3.7).
Sixty-three subjects (48%) developed at least one new disorder during the study interval.
Mots-clés Pascal : Antiphospholipide syndrome, Homme, Facteur risque, Etude cohorte, Exploration immunologique, Anticorps, Phospholipide, Gestation, Epidémiologie, Lupus like syndrome, Peau pathologie, Tissu conjonctif pathologie, Maladie système
Mots-clés Pascal anglais : Antiphospholipid antibody syndrome, Human, Risk factor, Cohort study, Immunological investigation, Antibody, Phospholipid, Pregnancy, Epidemiology, Lupus like syndrome, Skin disease, Connective tissue disease, Systemic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0287759
Code Inist : 002B07. Création : 199406.