Lung cancer mortality and polynuclear aromatic hydrocarbons : a case-cohort study of aluminum production workers in Arvida, Quebec, Canada.
The authors report the results of a case-cohort study of 338 lung cancer deaths in 1950-1988 and a random sample (sub-cohort) of 1,138 from among 16,297 men who had worked at least one year between 1950 and 1979 in manual jobs at a large aluminum production plant.
In the past, certain workers were exposed to substantial quantities of coal tar pitch volatiles, a mixture known to include polynuclear (polycyclic) aromatic hydrocarbons, and thus suspected to be capable of causing lung cancer.
After they controlled for the effects of smoking, the authors found that rate ratios rose with cumulative exposure to coal tar pitch volatiles measured as benzene-soluble material to 2.25 (95% confidence interval (CI) 1.50-3.38) at 10-19 mg/m3-years benzene-soluble matter, but did not rise further at higher exposures.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Mortalité, Exposition professionnelle, Toxicité, Composé aromatique polycyclique, Aluminium, Goudron houille, Homme, Epidémiologie, Québec, Canada, Amérique du Nord, Amérique, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Mortality, Occupational exposure, Toxicity, Polycyclic aromatic compound, Aluminium, Coal tar, Human, Epidemiology, Quebec, Canada, North America, America, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0280611
Code Inist : 002B11A. Création : 199406.