Should we consider a subject's knowledge of the etiologic hypothesis in the analysis of case-control studies ?
In the context of a case-control study of vitamin supplements and neural tube defects, Werler et al. (JAMA 1993;269:1257-61) have argued that respondents who are aware of the etiologic hypothesis might particularly be prone to misreport their exposure status.
They suggest that excluding such participants could offer the best chance for obtaining a valid risk estimate.
However, knowledge of an etiologic hypothesis can be the reason for a person's being exposed or nonexposed.
In addition, exposed cases selectively may become aware of the etiologic hypothesis after being diagnosed.
Mots-clés Pascal : Epidémiologie, Méthodologie, Biais méthodologique, Etiologie, Facteur risque, Connaissance, Malade, Homme, Etude cas témoin
Mots-clés Pascal anglais : Epidemiology, Methodology, Methodological bias, Etiology, Risk factor, Knowledge, Patient, Human, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0280610
Code Inist : 002B30A01A1. Création : 199406.