Risk excess of soft-tissue sarcoma and thyroid cancer in a community exposed to airborne organochlorinated compound mixtures with a high hexachlorobenzene content.
Unusually high levels of hexachlorobemene (HCB) were detected in the air and in sera of volunteers of a village located in the vicinity of an organochlorinated-compounds factory (Flix, Catalonia, Spain).
A significant increase for specific causes of death was obtained only for neoplasms of unknown origin, However, an excess of incident cases was observed for thyroid neoplasms, soft-tissue sarcoma and brain neoplasms in men.
These descriptive findings are in agreement with previously reported associations between soft-tissue sarcoma and human exposure to organochlorinated compounds, as well as with animal experiments relating HCB and thyroid cancer, and add new information on the possible relation between organochlorinated compounds, and particularly HCB, and cancer.
Mots-clés Pascal : Tumeur maligne, Thyroïde, Facteur risque, Sarcome, Partie molle, Organochloré, Pollution air, Incidence, Espagne, Europe, Homme, Thyroïde pathologie, Endocrinopathie, Peau pathologie, Benzène(hexachloro)
Mots-clés Pascal anglais : Malignant tumor, Thyroid gland, Risk factor, Sarcoma, Soft tissue, Organochlorine compounds, Air pollution, Incidence, Spain, Europe, Human, Thyroid diseases, Endocrinopathy, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0264536
Code Inist : 002B04B. Création : 199406.