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  1. Antibodies to the 4-mer repeat of the ring-infected erythrocyte surface antigen (Pf155/RESA) protect against Plasmodium falciparum malaria.

    Article - En anglais

    To investigate the protective role of antibodies to the ring-infected erythrocyte surface antigen (Pf155/RESA) epitopes against Plasmodium falciparum clinical malaria, a cohort study was conducted in a Malagasy village over 7 months.

    In the 304 individuals included, 127 experienced P. falciparum attacks of under 1500 parasites/mul with no clinical symptoms (protected individuals) and 177 experienced at least one clinical or preclinical P. falciparum attack requiring therapy (unprotected individuals).

    Antibodies to whole Pf155/RESA, to single epitopes of the 3' terminus, (EENV)4 and EENVEHDA(EENV)2 had higher responses in protected than in unprotected individuals (P=0.006, P=0.OO5, P=0.05 respectively).

    Mots-clés Pascal : Paludisme, Protozoose, Infection, Plasmodium falciparum, Sporozoa, Protozoa, Immunoprotection, Antigène, Surface cellulaire, Erythrocyte, Cellule infectée, Déterminant antigénique, Anticorps, Homme, Madagascar, Afrique

    Mots-clés Pascal anglais : Malaria, Protozoal disease, Infection, Plasmodium falciparum, Sporozoa, Protozoa, Immunoprotection, Antigen, Cell surface, Red blood cell, Infected cell, Antigenic determinant, Antibody, Human, Malagasy Republic, Africa

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0261618

    Code Inist : 002B05E02B4. Création : 199406.