We have previously reported on development of a DNA probe-based method for diagnosing Plasmodium falciparum infection directly from patient blood samples.
In the present studies, we sought to examine applicability of the method to large epidemiological surveys, comparing sensitivity, specificity, time required to obtain results, and costs with those of conventional microscopic examination.
Results of DNA probe hybridization were also compared between laboratories in the US and Thailand, to assess transferability of the DNA probe technology.
Five separate surveys of approximately 5000 villagers each were performed between December 1987 and June 1989 (26176 samples total).
Mots-clés Pascal : Paludisme, Protozoose, Infection, Plasmodium falciparum, Sporozoa, Protozoa, Epidémiologie, Surveillance sanitaire, Diagnostic, Homme, Sonde moléculaire, Technique, Thaïlande, Asie, Transfert technologie
Mots-clés Pascal anglais : Malaria, Protozoal disease, Infection, Plasmodium falciparum, Sporozoa, Protozoa, Epidemiology, Sanitary surveillance, Diagnosis, Human, Molecular probe, Technique, Thailand, Asia, Technology transfer
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0261617
Code Inist : 002B05E02B4. Création : 199406.