Familial clustering of hepatitis B virus infections and prevention of perinatal transmission by immunization with a reduced number of doses in an area of intermediate endemicity (Tunisia).
Hepatitis B surface antigen (HBsAg) was detected in 3.3% of 7162 pregnant Tunisian women tested and HBeAg in 9.6% of the HBsAg-positive mothers.
Family members of 46 of these HBsAg-positive mothers (33 husbands and 61 children aged 1-6 years) were investigated) for the presence of HBV markers.
HBsAg was detected in 21% of the children and 18% of the husbands.
Fifty children born to HBsAg-positive mothers received hepatitis B vaccine at birth, at the age of 2-3 months and at the age of 9 months.
After immunization, anti-HBs were detected in 92% of them with an anti-HBs geometric mean titre of 415 mIU ml-1.
Mots-clés Pascal : Femme, Virus hépatite B, Transmission, Antigène HBs, Enfant, Vaccin, Age, Vaccination, Gestation, Relation mère foetus, Immunoprotection, Tunisie, Homme, Hepadnaviridae, Virus, Afrique
Mots-clés Pascal anglais : Woman, Hepatitis B virus, Transmission, Hepatitis B surface antigen, Child, Vaccine, Age, Vaccination, Pregnancy, Fetomaternal relation, Immunoprotection, Tunisia, Human, Hepadnaviridae, Virus, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0230464
Code Inist : 002B30A03B. Création : 199406.