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  1. Halving of mortality at 1 year by domiciliary thrombolysis in the Grampian region early anistreplase trial (GREAT).

    Article - En anglais


    Our aim was to determine the time saved by administration of thrombolytic therapy at home rather than in the hospital and to assess whether earlier thrombolysis resulted in decreased mortality from acute myocardial infarction.


    There is much theoretic, experimenal and trial evidence to indicate that in acute myocardial infarction the earlier that thrombolytic therapy is given, the greater its efficacy.

    However, the clinical importance of this time effect is uncertain.


    In a randomized double-blind parallel-group clinical trial, 311 patients with suspected acute myocardial infarction seen by their general practitioners within 4 h of symptom onset were given intravenous anistreplase (30 U) either at home or later, after arrival in the hospital.

    Mots-clés Pascal : Infarctus, Myocarde, Homme, Anistréplase, Fibrinolytique, Chimiothérapie, Traitement, A domicile, Précoce, Mortalité, Epidémiologie, Appareil circulatoire pathologie, Cardiopathie coronaire

    Mots-clés Pascal anglais : Infarct, Myocardium, Human, Fibrinolytic, Chemotherapy, Treatment, At home, Early, Mortality, Epidemiology, Cardiovascular disease, Coronary heart disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0206645

    Code Inist : 002B02G. Création : 199406.