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  1. Human T-lymphotropic virus type I in Japan.

    Article - En anglais

    Adult T-cell leukaemia (ATL) was first reported in Japan, where it has a high incidence in the southwest region.

    The retrovirus human T-lymphotropic virus type I (HTLV-I) is the cause of ATL; and in ATL-endemic areas, the rate of carriage of antibodies to HTLV-I is high.

    A definite diagnosis of ATL is based on the presence of HTLV-I proviral DNA in the tumour-cell DNA.

    ATL cells originate from the CD4 subset of peripheral T cells.

    ATL shows diverse clinical features but can be divided into four subtypes-acute, chronic, smouldering, and lymphoma type.

    It is resistant to chemotherapy, and the acute and lymphoma types have a poor prognosis.

    Familial occurrence of ATL is common.

    HTLV-I infection is caused by transmission of live infected lymphocytes from mother to child, from man to woman, or by transfusion.

    Mots-clés Pascal : Hémopathie maligne, Immunopathologie, Infection, Epidémiologie, Etiopathogénie, Homme, Race, Mongoloïde, Virus HTLV1, Retroviridae, Virus, Japon, Asie

    Mots-clés Pascal anglais : Malignant hemopathy, Immunopathology, Infection, Epidemiology, Etiopathogenesis, Human, Race, Mongoloid, HTLV-I virus, Retroviridae, Virus, Japan, Asia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0197395

    Code Inist : 002B06D01. Création : 199406.