The natural history of trisomy 18 and trisomy 13 was investigated using data derived from parent questionnaires and medical records from 98 families with an index case of trisomy 18 and 32 families with an index case of trisomy 13.
Data are presented on pregnancy, delivery, survival, medical complications, immunizations, growth, cause of death, cytogenetics, and recurrence risk.
Half of the trisomy 18 babies were delivered by C-section.
Fetal distress was a factor in half, and the only reason in a third of C-section deliveries.
One minute Apgar scores were significantly lower in C-section and breech deliveries.
There were more small for gestational age babies than in the general population, but most of the low birth weight newborns were small for gestational age, unlike the general population.
Mots-clés Pascal : Chromosome D13, Trisomie, Aneuploïdie, Aberration chromosomique, Chromosome E18, Epidémiologie, Survie, Récurrence, Gestation, Complication, Croissance, Homme
Mots-clés Pascal anglais : D13-Chromosome, Trisomy, Aneuploidy, Chromosomal aberration, E18-Chromosome, Epidemiology, Survival, Recurrence, Pregnancy, Complication, Growth, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0191177
Code Inist : 002B23B. Création : 199406.