Prenatal diagnosis of trisomy 18 by amniocentesis in the latter half of pregnancy is now a common event.
Accurate prognostic information is crucial for families making decisions about delivery management.
Three recently published studies showed much shorter survival for trisomy 18 than was reported by earlier papers.
For this reason, we studied trisomy 18 survival.
We examined chromosome laboratory records to find all trisomy 18 diagnoses made in Utah between 1979 and 1988.
Death certificates and hospital records were used to determine survival.
We found 64 liveborn cases with trisomy 18 out of 388,563 total births over the 10-year period, a prevalence of 1/6071.
Mots-clés Pascal : Chromosome E18, Trisomie, Aneuploïdie, Aberration chromosomique, Homme, Survie, Epidémiologie, Conseil génétique
Mots-clés Pascal anglais : E18-Chromosome, Trisomy, Aneuploidy, Chromosomal aberration, Human, Survival, Epidemiology, Genetic counseling
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0189624
Code Inist : 002B23B. Création : 199406.