Parental consanguinity as a cause of increased incidence of birth defects in a study of 131,760 consecutive births.
The risk for birth defects in the offspring of first cousin parents is substantially higher than in the offspring of non-consanguineous parents.
As a general decline in the frequency of consanguineous marriages was observed in this century, one wonders whether consanguinity is still a factor in the appearance of birth defects in developed countries.
Based on our registry of congenital anomalies, we think that the answer to this question is « yes. » In the population studied in Northeastern France, consanguineous matings were known in 1.08% of the cases with congenital anomalies, vs. 0.28% in controls (P<0.001).
Mots-clés Pascal : Malformation, Pathogénie, Consanguinité, Epidémiologie, Homme, Maladie congénitale
Mots-clés Pascal anglais : Malformation, Pathogenesis, Consanguinity, Epidemiology, Human, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0189617
Code Inist : 002B23A. Création : 199406.