In a study of occupation and pregnancy outcome, information was collected on certain non-occupational factors including therapeutic drugs taken in the first trimester, reported by some 17% of women.
A case-referent analysis was made of data from pregnancies leading to 787 major (class 1) and 2386 miscellaneous minor (class 2) congenital defects compared with pregnancies without defects, matched for hospital, maternal age and educational level.
In pairs discordant for one of seven drug groups, ratios of positive pairs (case with drug) to negative pairs (referent with drug) were for class 1 defects 164: 148, relative risk (RR) 1.11 and for class 2 defects 433:383, RR 1.13.
Only anti-infective drugs showed an increased RR:1.70 (p=0.06).
Mots-clés Pascal : Médicament, Toxicité, Gestation, Premier trimestre, Malformation, Nouveau né pathologie, Tératogène, Nouveau né, Homme, Epidémiologie, Québec, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Drug, Toxicity, Pregnancy, First trimester, Malformation, Newborn diseases, Teratogen, Newborn, Human, Epidemiology, Quebec, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0173907
Code Inist : 002B02U10. Création : 199406.