Serum antioxidants and risk of rheumatoid arthritis.
Objectives-Oxygen free radicals have been implicated as mediators of tissue damage in patients with rheumatoid arthritis (RA).
Thus it is possible that several micronutrients acting as antioxidants and free radical scavengers provide protection against RA.
Serum alpha-tocopherol, beta-carotene, and selenium were studied for their associations with the risk of RA.
Methods-A case control study was nested within a Finnish cohort of 1419 adult men and women.
During a median follow up of 20 years, 14 individuals initially free of arthritis developed RA.
Two controls per each incident case were individually matched for sex, age, and municipality.
Serum alpha-tocopherol, beta-carotene and selenium concentrations were measured from stored serum samples.
Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Epidémiologie, Analyse biochimique, Sérum, Micronutriment, Antioxydant, Radical libre, Intercepteur radical, Concentration, Etude cohorte, Etude longitudinale, Finlande, Europe, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Exploration
Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Epidemiology, Biochemical analysis, Serum, Micronutrient, Antioxidant, Free radical, Radical scavenger, Concentration, Cohort study, Follow up study, Finland, Europe, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Exploration
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0162130
Code Inist : 002B15D. Création : 199406.