Patients with pauciarticular and polyarticular onset rheumatoid factor (RF) negative juvenile arthritis (JA) have been reported to have a variety of HLA associations.
The reason for the differences found in several recent studies is not known.
We compare a new series of patients investigated in Prague, Czechoslovakia with those we reported from Dallas.
Czech patients with JA (N=153) were classified clinically using the same criteria as in our studies in Dallas.
The RF negative group included 56 patients that had persistent pauciarticular disease, 42 pauciarticular with polyarticular course and 39 with polyarticular onset.
HLA class 11 alleles were determined by oligotyping as previously described from our laboratory.
Mots-clés Pascal : Rhumatisme inflammatoire, Enfant, Homme, Facteur risque, Système HLA, Antigène histocompatibilité classe II, Allèle, Exploration, Génétique, Biologie moléculaire, Epidémiologie, République tchèque, Europe, Système ostéoarticulaire pathologie, Arthrite chronique juvénile
Mots-clés Pascal anglais : Inflammatory joint disease, Child, Human, Risk factor, HLA-System, Class II histocompatibility antigen, Allele, Exploration, Genetics, Molecular biology, Epidemiology, Czech Republic, Europe, Diseases of the osteoarticular system, Juvenile rheumatoid arthritis
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0158281
Code Inist : 002B15D. Création : 199406.