To assess the epidemiologic characteristics of the population susceptible to hepatitis A virus (HAV) infection and determine the natural history of infection, a retrospective survey was done using banked serum specimens.
A random sample of 4030 Alaska Natives statewide was selected, stratified by year of birth and community of residence.
Overall, 1988 serum samples (49.3%) tested positive for antibody to HAV (anti-HAV).
Past HAV infection was strongly age-related, increasing from 7% in persons born since 1975 to 85% among persons born before 1945.
Prevalence of infection also varied between regions.
In small communities, a clear demarcation typically existed between previously infected older persons and younger anti-HAV-negative persons.
Mots-clés Pascal : Hépatite virale A, Virose, Infection, Virus hépatite A, Picornaviridae, Virus, Anticorps, Prévalence, Sérum, Age, Alaska, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Homme, Exploration immunologique, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Hepatitis A virus, Picornaviridae, Virus, Antibody, Prevalence, Serum, Age, Alaska, United States, North America, America, Epidemiology, Human, Immunological investigation, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0361842
Code Inist : 002B05C02G. Création : 199406.